![]() ![]() Gelatin is an irreversibly hydrolyzed form of collagen, wherein the hydrolysis results in the reduction of protein fibers into smaller peptides, which will have broad molecular weight ranges associated with physical and chemical methods of denaturation, based on the process of hydrolysis. Substances containing gelatin or functioning in a similar way are called “gelatinous”. The first commercial production of gelatin in the United States was in Massachusetts in 1808. The earliest commercial production of gelatin appears to have been in Holland around 1685, followed shortly thereafter in England about 1700. Severe allergic reactions, including anaphylaxis, have been reported following intravenous administration of modified fluid gelatins as plasma substitutes 2. Bovine and porcine gelatins, in particular, also have numerous applications throughout the pharmaceutical industry as integral components in drug capsules, plasma expanders, and stabilizers in vaccines, including MMR (measles, mumps and rubella), varicella (chicken pox), yellow fever, rabies, and some influenza vaccines. It is also found in lunch meats, and is used extensively as clarifying agents in wine, juices and other beverages. It is a common ingredient in foods such as jellies, sweets, yogurt and frozen desserts. Gelatin is commonly used as a gelling agent in food, pharmaceutical drugs, vitamin capsules, photography, and cosmetic manufacturing. Gelatin or gelatine is a translucent, colorless, brittle (when dry), flavorless. Gelatin is a protein derived from collagen and it is obtained principally from cow and pig bones and hides and fish skin 1.
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